General Descriptor Sparks Advancements in Dye Chemistry
SUTD: Xiaogang Liu, Weijie Chi, Chao Wang, Tee Meng Tan, Keegan Kang
DICP: Jie Chen, Wenjuan Liu, Qingkai Qi, Qinglong Qiao, Kangming Xiong and Zhaochao Xu
POSTECH: Xiao Liu and Yong-Tae Chang
SUTD collaborates with international researchers to move away from inefficient trial-and-error developments in dye chemistry and quantitatively design luminescent materials.
Researchers from SUTD, DICP, and POSTECH developed a theoretical descriptor ΔE for predicting PET-based fluorescence probes; utilizing this descriptor, they quantitatively designed fluorescent stains of lipid droplets and mitochondria for live-cell bioimaging.
There is an ongoing demand in biological research to accelerate the development of fluorescent probes based on the photo-induced electron transfer (PET) mechanism. By modulating PET formations, these probes significantly change fluorescence intensities, allowing a convenient route to monitor analytes or environmental changes with high sensitivity, vivid visibility and excellent spatiotemporal resolution.
You can find more details at https://www.sutd.edu.sg/Research/Research-News/2020/5/General-descriptor-sparks-advancements-dye-chem