With a focus on LKY World City Prize Network cities, this project seeks to develop a reference framework of actionable strategies for advancing urban innovation and systemic transformation through the integrative analytical lens of economic, social and environmental sustainability. Utilising international comparative research and case studies, the research examines urban innovation trends, good practice benchmarks and key urban development turning points that shape the conditions, challenges and successful inclusive sustainable development outcomes. Transferable lessons are distilled for peer learning, adaptation, and scaling.